the effects of 8 weeks of endurance training on α -1a protein of pre-synaptic p-q-type calcium channels in fast and slow muscles of rats

the purpose of this study was to investigate the effects of 8 weeks of endurance training (et) on ? -1a protein of pre-synaptic p-q-type calcium channels in fhl and soleus muscles of rats. 16 male wistar rats provided from razi institute, were randomly divided to 2 groups (control-sham; n=8 and endurance training; n= 8). training group performed 8 weeks (5 session/week) of endurance training on animal treadmill with 10 m/min for 30 min in the first week which was gradually increased to 30 m/min for 60 min(equal to 70-80% of vo2max) in the last week. 48 h after last session of training, fhl and sol muscles were removed under sterilized situation by cutting on posterio-lateral side of hind limb. measuring ?-1a protein with western blotting and independent t test showed that the amount of this protein insignificantly (p=0.177) increased in soleus muscles of et group (soleus: 14.82±87.44 vs. control: 20.20±72.57 (equal to 0/20 percent) and fhl: 7.26±70.83 vs. control: 6.28±70.01- p=0/839). this insignificant increase in ? -1a protein in soleus muscles, may indicate to the responsiveness of pre-synaptic p-q-type calcium channels of muscles following endurance training for improving ach release from pre-synaptic terminal, noted in nmj adaptations. in conclusion, it might be expressed that endurance training could be a main factor for the function of ?-1a protein in muscles and this case should be studied in future investigations with higher volume and intensities.